Carboxylestérase 1

CES1
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1MX1, 1MX5, 1MX9, 1YA4, 1YA8, 1YAH, 1YAJ, 2DQY, 2DQZ, 2DR0, 2H7C, 2HRQ, 2HRR, 3K9B, 4AB1, 5A7F, 5A7H, 5A7G
Identifiants
Aliases	CES1
IDs externes	OMIM: 114835 MGI: 2148202 HomoloGene: 35606 GeneCards: CES1
Nomenclature EC	3.1.1.1
Position du gène (Homme)
Chr.	Chromosome 16 humain
Fin	55,833,337 bp
Position du gène (Souris)
Chr.	Chromosome 8 (souris)
Fin	93,924,466 bp
Expression génique
	Fortement exprimé dans
	right lobe of liver; ; vésicule biliaire; ; poumon droit; ; olfactory zone of nasal mucosa; ; upper lobe of left lung; ; muscle lisse; ; apex of heart; ; muscle layer of sigmoid colon; ; Descending thoracic aorta; ; epithelium of colon;
	Fortement exprimé dans
	tissu adipeux blanc; ; glande lacrymale; ; vésicule biliaire; ; lobe pulmonaire droit; ; nasal epithelium; ; tunica adventitia of aorta; ; épithélium olfactif; ; superior surface of tongue; ; tissu adipeux brun; ; poumon gauche;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	methylumbelliferyl-acetate deacetylase activity; carboxylic ester hydrolase activity; activité hydrolase; sterol esterase activity; triglyceride lipase activity; methyl indole-3-acetate esterase activity;
Composant cellulaire	endoplasmic reticulum lumen; cytosol; réticulum endoplasmique; milieu extracellulaire;
Processus biologique	xenobiotic metabolic process; epithelial cell differentiation; réponse à une substance toxique; cholesterol ester hydrolysis involved in cholesterol transport; cholesterol biosynthetic process; medium-chain fatty acid metabolic process; lipid catabolic process; angiotensin maturation;
	Sources:Amigo / QuickGO
Orthologues
	1066
	104158
	ENSG00000198848; ENSG00000262243
	ENSMUSG00000056973
	P23141
	Q8VCT4
	NM_001025194; NM_001025195; NM_001266
	NM_053200
	NP_001020365; NP_001020366; NP_001257
	NP_444430
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

La carboxylestérase 1, appelée également hCE-1 (h pour « humain ») est l'une des carboxylestérases humaines, enzyme de type hydrolase.

Son gène est le CES1 situé sur le chromosome 16 humain.

Rôles

Elle permet l'hydrolyse de plusieurs substances dont la cocaïne et l'héroïne mais de manière moindre que la hCE-2^[5]. Elle hydrolyse également la mépéridine^[6].

Elle interviendrait probablement dans le métabolisme du cholestérol^[7] et dans celui de plusieurs médicaments, des mutations de son gène pouvant augmenter le taux sanguin de l'imidapril^[8] (un inhibiteur de l'enzyme de conversion), de la méthylphénidate^[9] ou diminuer celui de la forme active du dabigatran^[10].

Notes et références

1 2 3 ENSG00000262243 GRCh38: Ensembl release 89: ENSG00000198848, ENSG00000262243 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056973 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF, Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin, J Biol Chem, 1997;272:14769–14775
↑ Zhang J, Burnell JC, Dumaual N, Bosron WF, Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1, J Pharmacol Exp Ther, 1999;290:314–318
↑ Redinbo MR, Bencharit S, Potter PM, Human carboxylesterase 1: from drug metabolism to drug discovery, Biochem Soc Trans, 2003;31(Pt 3):620–624
↑ Geshi E, Kimura T, Yoshimura M et al. A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity, Hypertens Res, 2005;28:719–725
↑ Zhu HJ, Patrick KS, Yuan HJ et al. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis, Am J Hum Genet, 2008;82:1241–1248
↑ Paré G, Eriksson N, Lehr T et al. Genetic determinants of dabigatran plasma levels and their relation to bleeding, Circulation, 2013;127:1404-1412

Portail de la médecine
Portail de la biochimie

[refGRCh38Ensembl-1] 1 2 3 ENSG00000262243 GRCh38: Ensembl release 89: ENSG00000198848, ENSG00000262243 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056973 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Pindel_1997-5] Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF, Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin, J Biol Chem, 1997;272:14769–14775

[Zhang_1999-6] Zhang J, Burnell JC, Dumaual N, Bosron WF, Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1, J Pharmacol Exp Ther, 1999;290:314–318

[Redinbo_2003-7] Redinbo MR, Bencharit S, Potter PM, Human carboxylesterase 1: from drug metabolism to drug discovery, Biochem Soc Trans, 2003;31(Pt 3):620–624

[Geshi_2005-8] Geshi E, Kimura T, Yoshimura M et al. A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity, Hypertens Res, 2005;28:719–725

[Zhu_2008-9] Zhu HJ, Patrick KS, Yuan HJ et al. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis, Am J Hum Genet, 2008;82:1241–1248

[Paré_2013-10] Paré G, Eriksson N, Lehr T et al. Genetic determinants of dabigatran plasma levels and their relation to bleeding, Circulation, 2013;127:1404-1412

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